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IVF Will not Increase Ovarian Most cancers Danger: Research

IVF Won't Raise Ovarian Cancer Risk: Study

By Robert Preidt
HealthDay Reporter

THURSDAY, Nov. 19, 2020 (HealthDay Information) — Fertility remedies similar to in vitro fertilization do not seem to extend a lady’s danger of ovarian cancer, a brand new examine finds.

Earlier research steered that ladies who used this assisted reproductive applied sciences (ART) similar to IVF to get pregnant could also be in danger for ovarian cancer and non-malignant borderline tumors, as a consequence of elevated ranges of intercourse hormones wanted to stimulate egg manufacturing, in addition to a number of punctures disrupting ovarian tissue.

ART includes eradicating eggs from a lady’s ovaries surgically, fertilizing them in a lab after which putting them within the womb.

On this examine, researchers analyzed information from the Netherlands to check greater than 30,600 ladies who obtained ovarian stimulation for ART between 1983 and 2001 and practically 10,000 infertile ladies who did not obtain such therapy.

After a median follow-up of 24 years, the ladies had 158 invasive cancers and 100 borderline ovarian tumors. (Median means half had been adopted longer, half for much less time.)

Considerably, ladies who had ART didn’t have the next most cancers danger than infertile ladies who didn’t have ART — even after greater than 20 years had handed.

In contrast with ladies within the basic inhabitants, ladies who used ART did have the next ovarian most cancers danger.

Researchers stated this was primarily as a result of the next proportion of girls who obtained ART by no means had youngsters. Childlessness has been proven to be a powerful danger issue for ovarian most cancers, in accordance with authors of the examine revealed Nov. 17 in JNCI: Journal of the Nationwide Most cancers Institute.

Additionally they discovered that the chance of ovarian cancer decreased amongst ladies with a bigger variety of profitable ART cycles that resulted in childbirth.

In contrast with ladies within the basic inhabitants and infertile ladies who did not have ART, ladies who had ART had virtually double the percentages for borderline ovarian tumors, in accordance with the examine.

However the danger did not rise after extra therapy cycles or longer follow-up, suggesting that it’d owe to underlying affected person traits somewhat than ART itself, in accordance with the researchers.


Borderline tumors are uncommon within the basic inhabitants and customarily straightforward to deal with, they famous.

“Reassuringly, ladies who obtained ovarian stimulation for assisted reproductive know-how do not need an elevated danger of malignant ovarian most cancers, not even in the long term,” stated lead writer Flora van Leeuwen, an epidemiologist on the Netherlands Most cancers Institute in Amsterdam.

“Nevertheless, it is very important notice that even with the lengthy follow-up in our examine, the median age of the ladies at finish of follow-up was solely 56 years,” she stated in a journal information launch.

Noting that the incidence of ovarian most cancers within the inhabitants will increase at older ages, van Leeuwen stated it is very important observe ladies who’ve had ART even longer.

Extra info

For extra on ovarian most cancers, see the American Cancer Society.

SOURCE: JNCI: Journal of the Nationwide Most cancers Institute, information launch, Nov. 17, 2020

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